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W2 Professur Vaskuläres Remodeling und Regeneration

Alterungsprozesse sowie pathologische Umbauprozesse führen über die Entwicklung einer Atherosklerose zur Verengung und zum Verschluss von Blutgefäßen. Die Folgen sind ein akuter Herzinfarkt, eine chronische Herzschwäche, ein Schlaganfall oder eine verminderte Durchblutung der Extremitäten. Die krankhafte Veränderung der Blutgefäße im Rahmen der Atherosklerose ist somit die Hauptursache aller Herz-Kreislauf-Erkrankungen.

 

Unser Ziel ist es, die zellulären und molekularen Abläufe dieser Gefäßumbauprozesse besser zu verstehen, denn nur auf der Grundlage einer fundierten Kenntnis der Zusammenhänge lassen sich neue, effiziente und schonende Behandlungsstrategien entwickeln. Insbesondere interessieren uns die molekularen Abläufe in den Gefäßzellen, die dazu führen, dass diese Zellen ihre normale, physiologische Funktion verlieren.

 

Das übergeordnete Ziel ist es, über eine Beeinflussung dieser Steuermechanismen die normale Funktion der Gefäßzellen zu erhalten oder wieder herzustellen. Im Fokus unserer Arbeiten stehen hier insbesondere die Beeinflussung von microRNAs sowie von Signalmolekülen der Zellalterung in Endothel- und glatten Gefäßmuskelzellen. Dabei versuchen wir die Erkenntnisse aus unseren grundlagenwissenschaftlichen Untersuchungen schnell und gezielt in klinische Anwendungen umzusetzen, um so neue Verfahren zur verbesserten Therapie von Herz-Kreislauf-Erkrankungen zu etablieren.

 

Unser interdisziplinäres Forschungsteam arbeitet hier im Rahmen des Exzellenzclusters REBIRTH eng mit lokalen, nationalen und internationalen Wissenschaftlern und Forschungsverbünden zusammen.

Research Focus

The group has its main research interest in the field of vascular biology and medicine.

 

Specifically, we focus on signaltransduction and cell cycle regulation in vascular cells (smooth muscle- and endothelial cells) that modulate  vascular disease processes like atherosclerosis, restenosis and pulmonary hypertension.

By combining up to date molecular- and cell biology techniques with a wide range of animal models and clinical approaches, the Molecular Cardiology Lab provides a stimulating surrounding for it´s team members that gave rise to numerous high impact scientific observations in the past.

In translational approaches, our team uses the continuously growing basic science observations to develop novel strategies for the diagnosis, prevention and treatment of cardiovascular diseases.

 

Embedded in the sizzling and stimulating surrounding of Germanys „Excellence Cluster REBIRTH", and several DFG research training groups, the lab team works in close interaction and collaboration with local, national and international experts in the field on cutting edge questions of vascular proliferative disease.

The Group

The "Vascular Remodeling and Regeneration" section of the Dept. of Cardiology and Angiology of the Hannover Medical School (MHH) is a translational research unit, dedicated to combine cutting edge basic sciences with preclinical and clinical studies in the field of vascular heart and lung diseases. Research is organized on different levels of complexity such as identification of molecular signatures and signalling processes, assessment of cellular phenotypes and functions, integrative in vivo disease models and preclinical studies as well as clinical trials.

Misson

Diseases of the heart and blood vessels like atherosclerosis and ischemic heart disease are the most common causes of death in industrialized countries. Future progress in the treatment of cardiovascular disease can only be achieved by combining  basic science and applied clinical research. The UGMC has been established as a translational research unit dedicated to the development of novel strategies for the prevention and treatment of cardiovascular diseases.

People

The UGMC group led by Prof. Daniel Sedding consists of  basic scientists as well as clinical scientists, dedicated technicians and students, combining their knowledge, experience and efforts to push forward the field of cardiovascular research and medicine.

Awards and Honors
  • ERASMUS Placements Stipendium
    In August 2012 Jochen Dutzman received a ERASMUS Placements Stipendium for an extended research stay at the Harvard Medical School
  • Otto Hess Stipendium
    In May 2012 Jochen Dutzmann recieved the Otto-Hess-Stipendium from the German Society of Cardiology to finance his position for one year.
  • Albert Fraenkel Award
    In April 2011 Daniel Sedding received the Albert Faenkel Award from the German Society of Cardiology (DGK) due to outstandig achievements in basic cardiovascular science.
  • Best Poster Award
    In September 2009, Wiebke Bielenberg from the UGMC group recieved a Poster Award at the 5th European Meeting on Vascular biology and Medicine in Marseille, France
  • Young Investigator Award
    In July 2009, Wiebke Bielenberg from the UGMC group recieved a Young Investigator Award at the annual meeting of the International Society on Thrombosis and Haemostasis in Boston, USA 
  • Rudi Busse Young Investigator Award
    In April 2009, Daniel Sedding received the 1. Price in the Rudi Busse Young Investigator Award Session during the annual meeting of the German Cardiac Society in Mannheim, Germany
  • Young Investigator Award
    In April 2008 Wiebke Bielenberg from the UGMC group recieved the first place in the young investigator award session at the annual meeting of the German Society of Internal Medicine
  • Travel Award
    In August 2008, Wiebke Bielenberg from the UGMC group received a travel award for finishing the graduate program MBML with best grades.
  • Rene Baumgard Foundation
    In April 2008, Philipp Stieger from the UGMC group received the research award from the Rene Baumgart Foundation for his doctoral thesis work on the "protective effect of rapamycine on lung vascular remodeling and pulmonary hypertension" at the scientific meeting of the German Pneumology Society in Lubeck/Germany
  • Best Poster Award
    In March 2008, Wiebke Bielenberg from the UGMC group received the best poster award for her abstract on the "role of miRNA in atherosclerosis and restenosis" at the scientific meeting of the German Society of Internal Medicine in Wiesbaden/Germany.
  • Rudolf Thauer Poster Award
    In April 2007 Daniel Seddding received the Rudolf Thauer award from the German Cardiac Society for his abstract presentation on the "role of the Factor VII activating protease (FSAP) during vascular remodeling". 
  • Publication award
    In December 2007 Daniel Sedding received the publication award for the scientist with the highest impact publications from the department of Biochemistry, Giessen University.
  • Joung investigator award
    In September 2006 Daniel Sedding received the Joung investigator award at the Kardiology/Physiology Meeting in Lubeck/Germany for his abstract on "FoxO function during fascular remodeling". 
  • Best Poster Award
    In September 2005, Daniel Sedding received the poster award for his abstract on "FoxO-mediated caveolin-1 expression in vascular smoooth muscle cells" at the international vascular biology and medicine meeting, Hamburg/Germany
Publications

For a complete list of publications please click here:

www.ncbi.nlm.nih.gov

Prof. Dr. Daniel Sedding
Tel.: 0511 532-2129
Fax: 0511 532-3357
sedding.daniel@mh-hannover.de

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