zProf. Dr. Johann Bauersachs

Director of the Department of Cardiology and Angiology

Curriculum vitae
  • 1993
    Thesis (M.D.) at the University of Freiburg, Department of Physiology
  • 1993 – 1995
    Residency and Fellowship in Internal Medicine, University Hospital Frankfurt
  • 1995 – 1996
    Postdoctoral/Research Associate, Physiology, University of Frankfurt
  • 1996 – 1999
    Residency and Fellowship in Internal Medicine, University Hospital Mannheim
  • 1999 – 2003
    Residency and Fellowship in Internal Medicine and Cardiology, Department of Medicine, University of Würzburg
  • 1999 – 2004
    Scientific Secretary DFG Special Research Program SFB 355
  • 2000
    Board Certification „Internal Medicine“
  • 2002
    Board Certification „Cardiology“
  • 2001
    Habilitation, Member of the Faculty, senior lecturer, Dept. of Medicine, Division of Cardiology, University of Würzburg
  • 2003 – 2010
    Consultant Cardiology/Intensive Care, University Hospital Würzburg
  • 2006 – 2010
    Scientific Secretary DFG Special Research Program SFB 688
  • 2008
    Board Certification „Intensive Care”
  • 2008 – 2010
    Associate Professor, Dept. of Medicine I, University Hospital Würzburg
  • 2010
    Call for W3-Professorship Cardiology/Angiology, University Hospital Giessen
  • since 2010
    Full Professor and Director, Department of Cardiology and Angiology, Hannover Medical School
Special achievements/honors
  • 2001
    Oskar-Lapp- Award, „Deutsche Gesellschaft für Kardiologie“
  • 2004
    Albert-Fraenkel-Award, „Deutsche Gesellschaft für Kardiologie“
  • 2006
    Parmley-Award, American College of Cardiology
  • 2012
    Bernard and Joan Marshall Distinguished Investigator Award, British Society for Cardiovascular Research
  • 2018

    Paul Morawitz-Award, „Deutsche Gesellschaft für Kardiologie"

Patents
  • PCT/EP2007/008772: microRNA (miRNA) for the diagnosis and treatment of heart diseases
  • PCT/EP2009/051986: MicroRNA (miRNA) and downstream targets for diagnostic and therapeutic purposes
Speaker of
  • Clinical Research Group (KFO) 311
    (Pre-)terminal heart and lung failure – mechanical unloading and repair”
    Medical School Hannover; funded by the Deutsche Forschungsgemeinschaft (DFG) 2016-19
Member of
  • American Heart Association, Fellow
    Council on Basic Cardiovascular Sciences
    Council on Clinical Cardiology

  • European Society of Cardiology, Fellow
    Heart Failure Association (HFA), Fellow, Board Member
    Chair Committee Clinical Science Section
    Chair HFA Study Group Peripartum Cardiomyopathy

  • Deutsche Gesellschaft für Kardiologie - Herz- und Kreislaufforschung
    Member Program Committee

  • Deutsche Forschungsgemeinschaft, Fachkollegium Medizin
    Chair, Cardiovascular Section

President of

ESAC Germany (European Section of Aldosterone Council) Association

Editorial Board Member
  • Cardiovascular Research (Associate Editor), Current Heart Failure Reports (Associate Editor), Clinical Research in Cardiology, Basic Research in Cardiology, ESC Heart Failure, Herz – Cardiovascular Diseases

  • Deutsche Gesellschaft für Kardiologie - Herz- und Kreislaufforschung
    Member Committee Clinical Cardiovascular Sciences
Reviewer for

Deutsche Forschungsgemeinschaft, Deutsche Herzstiftung, Circulation, Circulation Research, Hypertension, Arteriosclerosis, Thrombosis and Vascular Biology, Journal of the American College of Cardiology, European Heart Journal, Cardiovascular Research, European Journal of Heart Failure, Journal of Molecular and Cellular Cardiology, British Journal of Pharmacology, European Journal of Clinical Investigation, Thrombosis Haemostasis, Endocrinology, American Journal of Physiology, Atherosclerosis, Diabetes, etc

Research interest

Professor Bauersachs is an interventional cardiologist with special interests in acute coronary syndromes, left ventricular healing and remodelling, acute and chronic heart failure, as well as intensive care. He is particularly interested in the pathophysiology and treatment of peripartum cardiomyopathy, in aldosterone and mineralocorticoid receptor-mediated mechanisms, and the role of non-coding RNAs

Important recent publications
  • Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomström-Lundqvist C, Cífková R, De Bonis M, Iung B, ..., Swan L, Warnes CA. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J. 2018, 39: 3165-3241. doi: 10.1093/eurheartj/ehy340.

  • Koehler F, Koehler K, Deckwart O, … Schulze PC, Bauersachs J, Wellge B, Schoebel C, Tajsic M, Dreger H, Anker SD, Stangl K. Efficacy of telemedical interventional management in patients with heart failure (TIM-HF2): a randomised, controlled, parallel-group, unmasked trial. Lancet. 2018 pii: S0140-6736(18)31880-4. doi: 10.1016/S0140-6736(18)31880-4.

  • Thackeray JT, Hupe HC, Wang Y, Bankstahl JP, Berding G, Ross TL, Bauersachs J, Wollert KC, Bengel FM. Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction. J Am Coll Cardiol. 2018 23, 71:263-275. doi: 10.1016/j.jacc.2017.11.024.

  • Hilfiker-Kleiner D, Haghikia A, Berliner D, Vogel-Claussen J, Schwab J, …..,  Podewski E, Böhm M, Sliwa K, Bauersachs J (2017). Bromocriptine for the Treatment of Peripartum Cardiomyopathy: A Multicenter Randomized Study. Eur Heart J 38, 2671-2679. doi: 10.1093/eurheartj/ehx355

  • Wollert KC, Meyer GP, Müller-Ehmsen J, Tschöpe C, ….. Dickstein K, Schultheiss HP, Ladage D, Greulich S, Bauersachs J (2017). Intracoronary autologous bone marrow cell transfer after myocardial infarction:  the BOOST-2 randomised placebo-controlled clinical trial. Eur Heart J, doi: 10.1093/eurheartj/ehx188

  • Appari M, Breitbart A, …., Wollert KC, Müller OJ, Bauersachs J, Heineke J (2017). C1q-TNF-related protein-9 promotes cardiac hypertrophy and failure by activating ERK5. Circ Res, Circ Res. 2017 Jan 6;120(1):66-77. doi: 10.1161/CIRCRESAHA.116.309398

  • Sliwa K, Mebazaa A, Hilfiker-Kleiner D, ….,  Ponikowski P, Bauersachs J. (2017) Clinical characteristics of patients from the worldwide registry on peripartum cardiomyopathy (PPCM): EURObservational Research Programme in conjunction with the Heart Failure Association of the European Society of Cardiology Study Group on PPCM. Eur J Heart Fail. Mar 8. doi: 10.1002/ejhf.780.

  • Bavendiek U,  Aguirre Davila L, Koch A,  Bauersachs J (2017). Assumption versus evidence – the case of digoxin in atrial fibrillation and heart failure. Eur Heart J, Jan 8. pii: ehw577. doi: 10.1093/eurheartj/ehw577

  • Bauersachs J, Arrigo M, Denise Hilfiker-Kleiner DF, ....., Seferovic P, Tavazzi L, Ruschitzka F, Mebazaa A, Sliwa K (2016). Current management of patients with severe acute peripartum cardiomyopathy: Practical guidance from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy. Eur J Heart Fail, Sep;18(9):1096-105. doi: 10.1002/ejhf.586.

  • Zwadlo C, Schmidtmann E, Szaroszyk M, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bahre H, Kaever V, Thum T, Bauersachs J, Heineke J. Anti-Androgenic Therapy with Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction. Circulation. 2015;131:1071-1081.

  • Hilfiker-Kleiner D, Haghikia A, Nonhoff J, Bauersachs J. Peripartum cardiomyopathy: current management and future perspectives. Eur Heart J. 2015;38:1090-1097.

  • Bauersachs J, Jaisser F, Toto R (2015). Mineralocorticoid Receptor Activation and Mineralocorticoid Receptor Antagonist Treatment in Cardiac and Renal Diseases. Hypertension. 2015;65:257-263.

  • Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature. 2012;485:333-338.

  • Fraccarollo D, Berger S, Galuppo P, Kneitz S, Hein L, Schutz G, Frantz S, Ertl G, Bauersachs J. Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction. Circulation. 2011;123:400-408.

  • Bauersachs J, Thum T. Biogenesis and regulation of cardiovascular microRNAs. Circ Res. 2011;109:334-347.

  • Thum T, Schmitter K, Fleissner F, Wiebking V, Dietrich B, Widder JD, Jazbutyte V, Hahner S, Ertl G, Bauersachs J. Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans. Eur Heart J. 2011;32:1275-1286.

  • Thum T, Gross C, Fischer T, Fiedler J, Just S, Rottbauer W, Bussen M, Galuppo P, Frantz S, Castoldi M, Muckenthaler M, Soutschek J, Koteliansky V, Rosenwald A, Bauersachs J*, Engelhardt S*. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008;456:980-984. *joint senior authors

  • Fraccarollo D, Galuppo P, Schraut S, Kneitz S, van Rooijen N, Ertl G, Bauersachs J. 

    Immediate Mineralocorticoid Receptor Blockade After Myocardial Infarction Improves InfarctHealing by Modulation of the Inflammatory Response. Hypertension. 2008;51:1-10.

  • Fraccarollo D, Widder JD, Galuppo P, Thum T, Tsikas D, Hoffmann M, Ruetten H, Ertl G, Bauersachs J.  Improvement of left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction. Circulation. 2008;118:818-827.

  • Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J. MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure. Circulation. 2007;116:258-267.

Prof. Dr. Johann Bauersachs
Tel.: +49 511 532-3841
Fax: +49 511 532-5412
ratic.angelina@mh-hannover.de

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